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You will see it stated confidently in a lot of places that the body adapts after 4 to 6 weeks, tolerance builds, and the effect fades, so you have to cycle. It sounds authoritative

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Specifically, recent approaches include Gln supplementation to strengthen TJ protein expression, Cys and Gly supplementation to boost antioxidant defenses, and enzymatic therapies (such as Cys proteases, EP-B2, and RmuAP1) to break down immunogenic gluten peptides