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Likewise, there is preserved and rescued intestinal mucosal integrity and vein integrity, reversed portal hypertension along with recovery of bile duct ligationinduced cirrhosis in rats (Sever et al., 2019), and reduced or even normal MDA levels in both ischemic and reperfusion conditions in various tissues (i.e., colon, duodenum, cecum, liver, and veins) and plasma (Amic et al., 2018

513 NMNAT, as a binding partner of HSP90, can specifically recognize p-Tau to inhibit its amyloid aggregation in vitro and reduce its symptoms in the fly tauopathy model, and this effect could be competitively destroyed by its enzymatic substrate

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