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The activation of the AGE-RAGE axis amplifies chronic inflammation and oxidative stress in both microenvironments, while SNS overactivity and elevated catecholamines induce vasoconstriction in both testicular and penile vasculature, forming a vicious cycle of sympathetic activation and inflammatory damage (207)

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Only approximately 1-4% gets absorbed via the gut, so taking B12 sublingually is the best absorption avenue (holding it under the tongue or between the gums and cheek is most common)

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