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This hormonal effect accounts for sexual characteristics changes in immune function, and the higher susceptibility of women to autoimmune diseases like SLE ( It will be crucial to distinguish the interplay of gut microbiota and the sex hormones as it can potentially unlock the mechanisms of higher susceptibility of females to SLE and also unveil novel avenues of therapeutic intervention by manipulation of the gut microbiome for controlling disease course ( 3 Probiotics and systemic lupus erythematosus Probiotics are live microorganisms significant for their role in immunomodulation in SLE patients, as they restore gut microbiota balance and enhance immune function

doi: 10.1016/j.bmc.2019.06.040 92 GuoSZhaoWZhangWLiSTengGLiuL

IGF-1 does both

Centella Asiatica Extract: Known for its healing properties, it helps to soothe and repair the skin

This investigation was supported by grants provided by the Geneva Cancer League, CANSEARCH, Hans Wilsdorf, Telemaque and Charles Bruneau foundations

Its absence has kept the endogenous biology of DSIP unanchored