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The glycolytic intermediate 3-phosphoglycerate bypasses glycolysis to produce serine, using NAD + as a redox cofactor

Comp Biochem Physiol 130C:289303 Rossi R, Dalle-Donne I, Milzani A, Giustarini D (2006) Oxidized forms of glutathione in peripheral blood as biomarkers of oxidative stress

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As for the culture environment in vitro, where only AML cells are present, orid-liposome-MAL can non-competitively enter all AML cells, causing REDOX imbalance and exerting its anti-tumor effects

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