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Finally, the insertion of Sec at the UGA codon is facilitated through the recognition of a unique selenocysteine insertion sequence (SECIS) present in the three prime untranslated region (3-UTR) of mRNAs of seleno-GPxs by ribosomes with the help of SECIS binding protein (SBP)

The OPTION-DM trial was a multicenter, randomized, crossover study comparing three monotherapy sequences (amitriptyline, duloxetine, pregabalin) against two dual-therapy sequences in patients who had failed one monotherapy [65]

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Psychiatry 57 , 217220 (1994)