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As a secondary messenger of free radicals and growth regulators, 4-HNE participates in various pathophysiological processes and act as a bioactive marker, especially in oxidative stress related to diseases (111)

Combination of GSH, amikacin and DNase-I showed the greatest reduction in MRAB biofilm viability

Since peptides, proteins, and hormones can directly reach the brain when administered intranasally via transport and diffusion along the olfactory and trigeminal nerves [241], future studies should explore whether intranasal melatonin could be a viable therapeutic option for increasing brain melatonin levels in individuals at risk of developing AD

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For instance, in oral pills, the retention is not extended, with little absorption