CoQ10 is also a potent anti-inflammatory agent that effectively down-regulates cytokines (i.e., TNF-, IL- 6, CRP) and could optimize viral-disrupted ACE2/RAAS system, by exerting anti-angiotensin II effects and decreasing OxS in COVID-19 patients 537,538
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During simulated human gastrointestinal digestion, polyethylene microparticles significantly increased the relative abundance of pathogenic bacteria, including Clostridium , Bacteroides , and Escherichia [71]
Collectively, these findings suggest that sleep disruption associated with circadian misalignment may impair mitochondrial function and compromise cellular health, leading to redox imbalance and contributing to accelerated aging phenotypes
