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Additionally, PABA showed strong anticoagulant and beneficial agent effects (180, 183)

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3.3 Effects of metformin on angiogenesis in endometriosis Angiogenesis is fundamental to the growth of endometriotic tissue, which starts with the destabilization of the pre-existing vasculature, and is driven by the release of pro-angiogenic factors and the degradation of the extracellular matrix (ECM)