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Research shows that CML cells with the BCR-ABL-T315I mutation treated with AKI603 display features typical of senescent cells, such as increased SA--Gal activity, altered morphology, elevated levels of p53, p21, p27, and p16, as well as SASP secretion [79]
Importantly, BPC-157 demonstrates no interference with normal bone remodeling processes, maintaining the balance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption necessary for proper structural regeneration
