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The progressive degeneration of DA neurons in the substantia nigra is accompanied by elevated iron levels and diminished glutathione content, both of which heighten cellular susceptibility to ferroptosis
ROS-induced damage contributes to the demyelination in MS
Understanding breast cancer complexity to improve patient outcomes: The St Gallen International Consensus Conference for the primary therapy of individuals with early breast cancer 2023
Mechanistically, an expanding body of preclinical/translational research suggests that the gut-microbiome impacts breast carcinogenesis and therapy through several interrelated pathways-chiefly in terms of its estrobolome (microbial pool of genes dedicated to estrogen metabolism), bioactive microbial metabolite synthesis, systemic/mucosal immunity modulation (influencing T-cell subsets/myeloid cell function/inflammatory cytokine networks) also together with drug pharmacokinetics/pharmacodynamics (175)
These context-dependent properties have also been exploited therapeutically to achieve tumor-selective cytotoxicity
In research focused on the nervous system, GHK has demonstrated neuroprotective effects in models of neurodegenerative diseases and improved tissue regeneration
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