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Staphylococcus aureus mastitis isolates produce EVs containing -haemolysin, which, upon stimulation of bovine mammary epithelial cells in vitro, induce TNF- upregulation, demonstrating that pathogen-derived EVs can directly modulate mammary epithelial immune responses independent of systemic gut-derived signals

& Dengjel, J

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43, 44 Urotensin-II has also been shown to function as a potent vasodilator in some isolated vessels

Santacroce, G., Gentile, A., Soriano, S., Novelli, A., Lenti, M