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Vitamin B12: Vitamin B12 deficiency can also lead to anemia, as well as fatigue

As such, fentanyl may act on peripheral structures, brain regions without a bloodbrain barrier, and brain structures within the blood brain barrier 15,20

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Note: Epithalon is not approved by the FDA for medical use

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Therefore, as soon as MTX treatment starts, routine monitoring of serum creatinine and plasma MTX levels is crucial to predict the onset of renal failure