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This cytokine modulation appears to be a key mechanism underlying its efficacy in models of inflammatory bowel disease, surgical wound healing, and systemic inflammatory injury

Critical role of oxidative stress and sustained JNK activation in aloe-emodin-mediated apoptotic cell death in human hepatoma cells

In tissues, the ketosteroid isomerase reactions catalyzed by GSTs are strictly dependent on dehydrogenases such as 3-hydroxysteroid dehydrogenase and 17-hydroxysteroid dehydrogenase for production of the 3-keto substrates from the corresponding 3-hydroxysteroid precursors, since the GSTs are lacking dehydrogenase activity

Int J Mol Sci (2019) 20(24):6268

Ghrelin administration in humans increases both circulating GH and SST levels, suggesting that hypothalamic, but not peripheral, SST production is involved in GH secretion regulation [33]

, Lukey Michael J., Cerione Richard A., and Locasale Jason W