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The proposed mechanism involves NNMT inhibition increasing the SAM:SAH ratio and NAD+ precursor availability, activating sirtuin-mediated metabolic programs

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A circular intronic RNA ciPVT1 delays endothelial cell senescence by regulating the miR-24-3p/CDK4/pRb axis

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Phosphorylated CREB binds DNA at CRE sequences activating genes supporting neuronal survival, plasticity, and function

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