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We interpret these results to mean that the glutathione system acts throughout the eukaryotic kingdom as the major mediator of antioxidative electron flux in response to acute oxidative challenge

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3.1.2 Alkylating agents Alkylating agents represent a distinct category of anticancer drugs with a mechanism of action centered on the formation of an unstable alkyl group R-CH2+, which subsequently reacts with nucleophilic centers on proteins and nucleic acids