The clinical translation of nanomedicines for melanoma faces multiple challenges, including scalability and manufacturing complexities (e.g., difficulties in large-scale production of biomimetic nanoparticles under GMP standards), safety and immunogenicity concerns (such as unintended immune responses and limited long-term toxicity data), and biological barriers like tumor heterogeneity and the immunosuppressive TME
Pain-related pathology, especially pain of an unknown etiology, is a significant challenge in clinical practice, and the limitations of traditional pain-relief mechanisms have made it necessary to explore alternative approaches
used in some protocols but less characterised
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