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This condition can be triggered by factors such as excessive alcohol consumption, prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDs), or infection with Helicobacter pylori bacteria

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Currently, only two germ line missense mutations of c-MET have been found within B cell lymphoma, especially DLBCL (R1166Q in the tyrosine kinase domain in one patient and R988C in the juxtamembrane domain in four patients) [28]

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