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References: Seiwerth, S., Rucman, R., Turkovic, B., Sever, M., Klicek, R., Radic, B., & Sikiric, P

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A cohort study of 20 transmasculine patients found that facial and truncal acne increased over 4 months of testosterone treatment, from 35% to 82% and 15% to 88% respectively

Nature 490 , 6170 (2012)

This enzyme subsequently activates caveolin-1, which releases endothelial nitric oxide synthase (eNOS) from its inhibitory binding