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nAChRs are ligand-gated ion channels composed of five transmembrane subunits, with the 4 2 receptor subtype being the most common in the brain, playing a crucial role in the behavioral effects of nicotine

BertelsenRJBrantsterALMagnusMCHaugenMMyhreRJacobssonBet al (2014)

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In these STEP trials, most participants experienced mild to moderate symptoms, with the incidence of severe side effects being 9.8% in the semaglutide treatment group and 6.4% in the placebo group