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As a long-acting IGF-1 analog, the compound represents a research subject in the broader field of peptide stability engineering specifically the use of structural modifications including N-terminal extension and amino acid substitution strategies to extend peptide half-life and modify peptide-binding protein interactions compared to native IGF-1 sequences

In fact, a prior study demonstrated that children residing in konzo-prone regions of the DRC had a collective micronutrient deficiency that trended with disease severity, but such deficiencies are commonplace in populations across sub-Saharan Africa including those with low incidence of konzo 18

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Like semaglutide, it reduces food intake and appetite by mimicking hormones

doi: 10.1039/9781837676323-00234 91 GoelV.PandeyD.ShuklaS