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PATHOLOGICAL ALTERATIONS OF GSTP1 METHYLATION PATTERNS Beyond DNA hypermethylation, which was the first epigenetic alteration to be discovered as an influencing factor for GSTP1 expression, histone modifications were discovered in the early 2000 s to play a regulating role in GSTP1 expression

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The application-sacrifice periods were ligation times of 030 min, 05 h, 024 h (cured periods, early regimen) and 4.30 h5 h, 5 h24 h (cured periods, delayed regimen)