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In the acute phase, the neuroinflammatory response worsens BBB injury by degrading tight junctions and the extracellular matrix, promoting neuroglial proliferation, and activating cardiomyocytes, thereby further increasing its permeability

AJNR Am J Neuroradiol 41(5):844-851, 2020

(PubMed) Arai H, Kono N

The phenolic hydroxyl group contributes additional hydrogen bonding capacity, while the aliphatic chain increases hydrophobic character relative to shorter peptide analogues

Current Pharmaceutical Design, 26(25), 2991-3000

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