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Laboratory investigations primarily focus on its influence over fibroblast activity, collagen type I synthesis, and the physiological signaling pathways within isolated follicle cell cultures
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(2001) preclinical study (PMID 11285201) demonstrating that the C-terminal fragment of hGH (residues 177-191, the basis of AOD-9604) inhibits fat cell formation in 3T3-L1 cells, establishing the rationale for AOD-9604 as a lipolytic agent
In a similar study, the pivotal role for the IGF-1 in insulin sensitivity has received further support from liver-specific IGF-1 KO mice which exhibited overt insulin resistance and hyperinsulinaemia that was reversed by the administration of IGF-1 [161]
The GRAS determination was likely based on the compound's limited systemic absorption (when ingested), short plasma half-life, and lack of acute toxicity signals in the Phase 2b obesity trial
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