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A 2020 review of case reports found that self-administered coffee enemas caused adverse effects such as: abdominal pain bloody stool rectal pain or burning proctocolitis, or inflammation of the rectal lining colitis, or inflammation of the colon The review also noted three deaths following coffee enema

Additionally, although the thiolactone form has not been unequivocally identified in vivo , homocysteine could undergo intracellular cyclization into homocysteine thiolactone, which could be a major by-product of impaired homocysteine metabolism (Jakubowski, 1997

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doi: 10.1212/01.wnl.0000140291.86406.d1 65 WilletteAAXuGJohnsonSCBirdsillACJonaitisEMSagerMAet al

Is nausea a sign that the medicine is working

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