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22 Unfortunately, chemotherapeutic agents acting on the mTOR pathway have not been discovered to improve social interaction of children with tuberous sclerosis

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Documentation and related records Documentation status: Purity + Endotoxin COA

The most well-characterized pathway involves direct activation and upregulation of vascular endothelial growth factor receptor 2 (VEGFR2)

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First, SELECT was designed as a CV outcomes trial and not a weight-loss trial, and weight loss was only a supportive secondary endpoint in the trial design