Wang C, Chen YW, Zhang L, et al
GHK-Cu (Copper Tripeptide-1) is a natural tripeptide (Gly-His-Lys) combined with a copper ion (Cu)
***May impair activity and attention in children
Endogenous concentrations decline with age, driving research interest in its roles in tissue maintenance, wound repair, and hair follicle biology
Phase 2 trial results (48 weeks, adults with obesity): 1 mg dose: 7.2% body weight loss 4 mg dose: 12.9% body weight loss 8 mg dose: 17.3% body weight loss 12 mg dose: 24.2% body weight loss Placebo: 1.6% body weight loss Phase 3 TRIUMPH-4 results: 9 mg dose: 20.0% body weight loss (22.9 kg / 50.5 lbs) 12 mg dose: 23.7% body weight loss (27.2 kg / 60.0 lbs) Placebo: 4.6% body weight loss In a separate phase 3 analysis, retatrutide at the highest dose achieved up to 28.7% weight loss
In a recent study, cereal fortification, providing 499 and 665 g of folic acid daily, increased plasma folic acid by 64.8% and 105.7%, respectively, and decreased plasma homocysteine by 11% and 14%, respectively (Malinow et al, 1998)
