Overproduction of ROS can also lead to DNA damage
[DOI] [PMC free article] [PubMed] [Google Scholar] 22.Hall JA, Cannons JL, Grainger JR, et al
Whats more, the aforementioned study casts light upon some of the unfairly neglected benefits of the conversion of L-citrulline into L-arginine, including increased blood flow and vasodilation
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Humanin also modulates the activities of caspases, key mediators of cell death pathways, thereby promoting cell survival in stressful conditions (Nakagawa et al., 2002)
The translation to the bedside of this therapeutic compound has shown to be safe in humans and effective in lowering MMP-9 levels in treated patients (253, 254), with some neuroprotective effects (255), but it does not yield firm evidence on HT prevention
