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Significance of glutathione-dependent antioxidant system in diabetes-induced embryonic malformations

When mechanical stress on blood vessels and the heart increases, and oxidative stress and inflammation occur, mitochondrial damage is inevitable

For example, in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced mouse model of PD

At the end of this 7-day labelling period ( t = 0 h), samples were collected to verify complete incorporation of the heavy label into cellular proteins

In recent in vitro assays performed by our group [32], we showed that H 2 O 2 -induced oxidative stress triggered the binding of Prx2 and GPx to RBC membrane