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Among these, syn oligomers (synOs) are considered highly neurotoxic due to their ability to induce mitochondrial dysfunction, impair synaptic transmission, damage cellular membranes, and trigger intracellular inflammation and lysosomal stress [11]

Zavodnik I, Buko V, Lukivskaya O, Lapshina E, Ilyich T, Belonovskaya E, Kirko S, Naruta E, Kuzmitskaya I, Budryn G, Zyzelevicz D, Orach J, Zakrzeska A, Kiryukhina L (2019) Cranberry peel polyphenol-rich extract attenuates rat liver mitochondria impairments in alcoholic steatohepatitis in vivo and after oxidative treatment in vitro

With prolonged or high-dose use, receptors may become less responsive, making the peptide less effective

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Addiction, Abuse, and Misuse Inform patients that the use of hydrocodone bitartrate and acetaminophen tablets, even when taken as recommended, can result in addiction, abuse, and misuse, which can lead to overdose and death (see WARNINGS)