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Furthermore, it has been established that some of the extraneuronal A is derived from intraneuronal sources (Oddo et al., 2006)

Lipoyl (octanoyl) transferase 2 catalyzes the transfer of the octanoyl moiety from ACP to a conserved lysine in the H protein of the glycine cleavage complex (see Biological Activities and Figure 3)

Additionally, others may have mutations in their GPX/GST and other genes that put them at risk for low glutathione levels or higher oxidative stress levels