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Trouble arises when the body produces too much or struggles to break it down, leading to intolerance

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Microglia impede oligodendrocyte generation in aged brain

doi: 10.1111/j.1460-9568.2004.03765.x 181 SumnerC

These can be seen by putting a drop of fluid on a slide and examining it using a polarizing microscope, which takes advantage of the way uric acid crystals bend light