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Cyanocobalamin is the form of vitamin B12 with the longest clinical history

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Effects on glycemic control, IGF-I levels, and safety profile

Potential concerns include effects on angiogenesis that theoretically could influence tumor development or progression, though preclinical studies show context-dependent effects that inhibit pathological angiogenesis in some tumor models

Contemporary trial data in high risk patient groups do not show convincing evidence that intensive lipid lowering causes major neurocognitive harm, dementia, or a clear excess of haemorrhagic stroke in selected patients, even at very low achieved LDL-C levels [9], [10], [11], [12], [13], [14], [15], [16]

There is a lack of large randomized clinical studies evaluating the effectiveness in autoimmune diseases