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What's more, constant, high-intensity physical activity causes wear and tear in the connective tissues

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Systemic nitric oxide production decreases[11]

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When combined with dietary chronotherapy e.g., morning exercise plus high-protein breakfast, and avoidance of caffeine or heavy meals late in day the synergistic effect can be substantial in restoring a robust 24-h rhythm ( These interventions may support functional resilience and circadian regulation under age-related physiological constraints

The Puglielli lab is supported in part by the NINDS (NS094154 to L.P.), the NIGMS (GM148487 to L.P.) and the NIA (AG078794 to L.P.)