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Toxicity of ZIL and DMSO to iPS cells iPS cells were removed from dishes at 80% confluence using CTK solution and washed DPBS ()

Image from Kraskovskaya et al

Nature 478 , 483489 (2011)

Skeptics counter that those figures come from voluntary reporting rather than controlled trials, and that questions remain about immunogenicity, whether the body mounts an immune response to the peptide

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Diagnostic steps: Review baseline and current measurements objectively (visual acuity, visual field, OCT imaging), ensure consistent daily peptide use without extended gaps, verify proper dosing and administration technique, confirm appropriate peptide choice for specific condition