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In renal biopsy tissue studies of CKD patients and mice models including UUO and renal ischemia-reperfusion injury, downregulation of GPx4 and upregulation of 4-hydroxynonenal were observed

214 Moreover, resveratrol improves gut microbiota composition and intestinal barrier integrity, limiting endotoxin transfer

HFD and Met and choline-deficient diet (MCD) can mimic human diseases histological and metabolic abnormalities and are commonly used to establish NAFLD mouse models

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Lastly, during oxidative insult, aldehydes are formed as a byproduct