Once acclimated to B12 therapy, most individuals dont experience detox reactions or concerns of feeling worse after each B12 injection
This does not mean tirzepatide is "stronger." The two molecules have different potencies, receptor binding profiles, and pharmacokinetics
PubMed Sikiric, P., Hahm, K.B., Blagaic, A.B., Tvrdeic, A., Pavlov, K.H., Petrovic, A., Kokot, A., Gojkovic, S., Krezic, I., Drmic, D., Rucman, R., & Seiwerth, S
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PMID: 11325542 | doi:10.1016/s0304-4165(01)00127-1 Pickart L et al
Boban-Blagaic A, Blagaic V, Romic Z, Sikiric P