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In pancreatic cancer cells, oncogenic K-Ras maintains the nucleotide pool via the MAPK-dependent signaling pathway, leading to MYC upregulation, and the use of MEK inhibitors reduces the incorporation of glutamine-derived nitrogen into purine nucleotides 38
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117 older adults, interventional group)
Additionally, some CXCR2 inhibitors, such as danirixin and elubrixin, which were initially developed for treating non-cancer diseases, are being repurposed for cancer treatment with encouraging prospects
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