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Freckles (Ephelides) Freckles, also known as ephelides, are small, light brown spots that appear symmetrically across the cheeks and under the eyes, mainly around the nose

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The most frequently initiated biologic class was interleukin (IL)-23 inhibitors (41.0% [673/1640]), followed by IL-17 (34.4% [564/1640]), tumor necrosis factor (16.4% [269/1640]), and IL-12/23 (8.2% [134/1640]) inhibitors