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The peptides oral bioavailability is low (58%), but it accumulates preferentially in inflamed colonic tissue, making systemic absorption less critical

Cazzola, M., Calzetta, L., Page, C., Jardim, J., Chuchalin, A.G., Rogliani, P., Matera, M.G

Sometimes the issue is not the medication itself but lifestyle factors

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Topical formulations are also available for skin-focused applications, but injectable delivery achieves higher tissue concentrations and is the standard for clinical protocols