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Cartilage faces even greater obstacles given avascular nature (no blood vessels penetrating tissue), low cell density (chondrocytes sparse within extensive extracellular matrix), minimal metabolic activity (slow turnover and repair), and mechanical loading challenges (constant stress impeding healing)

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The goal is to obtain optimum fitness in each of these, since theyve been shown to form a powerful shield against our biggest health threats: cardiovascular disease, cancer, metabolic dysfunction, and degenerative neurological disorderswhat Attia refers to as the four horsemen. Fitness sounded like good medicine to me, but the emphasis on exercise also prompted a lot of questions: What kind

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A review in the Annals of the New York Academy of Sciences on Thymosin Beta-4 mechanisms in tissue repair and regeneration

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