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Immunol Lett

Accumulated evidence suggests that increased TNF production plays a central role in the pathogenesis of NAFLD, especially in its progression to NASH

For instance, the total NADP(H) is about 420 nmol/g wet weight in rat liver and 59% of total NADP(H) is found in mitochondria, and 30 nmol/g wet weight in skeletal muscle, 5,8 and the NADPH concentration in the cytosol is 3.1 0.3 and 37 2 M in the mitochondrial matrix in HeLa cells

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Regulation of Nrf2-an update