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Severe hypokalaemia (low blood potassium) is rare but can develop in some cases, particularly in severe megaloblastic anaemia or in patients taking certain medications such as diuretics

Side effects of B12 deficiency can include decreased cognitive function, fatigue, lethargy, feeling faint, depression or irritability, headache, balance issues and more

It holds promise in various disease conditions, particularly in inflammatory bowel disease (IBD) treatment, where it has shown substantial

A biotin deficiency can lead to brittle hair and nails

While short-term preclinical studies suggest favorable safety, chronic administration effects on angiogenesis, growth factor signaling, and tissue remodeling over years of use remain unknown

2021;372:n136