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In HPG axis terms, peptideinduced increases in IGF1 may blunt central inhibitory signals and re-establish more youthful gonadotropin rhythms

The most common side effects reported in trials include mild to moderate gastrointestinal issues: nausea, diarrhea, vomiting, and constipation

Shan X, Yu W, Ni X, et al

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So the synergy argument is mechanistic extrapolation supported by class-level research: stronger than the reasoning behind many peptide stacks, but still not a trial of these two compounds together, and it is honest to say so