Weight management A 2018 meta-analysis of randomized, placebo-controlled trials found that lipoic acid supplementation in those with high body mass index (BMI) resulted in significant, yet modest, reductions in weight (9 studies) and BMI (11 studies) in the absence of caloric restriction (except in one study) (105)
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Some probiotic strains, such as Lactobacillus and Bifidobacterium , have been shown to reduce the production of reactive oxygen species (ROS) and enhance the activity of antioxidant enzymes (Yang et al., 2020a
Neither berberine alone nor tirzepatide alone has a strong propensity to cause hypoglycemia in people with normal pancreatic function who are not also taking insulin or secretagogues
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Arginase 1 (cytosolic isoform) expression in MDSCs is also important for the suppressive function of these cells, restraining Teffs-mediated antitumor immunity and promoting both Teffs cell death and Tregs suppressive effects [85, 86]