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The PICOs elements were defined as follows: P (Participants): subjects of any age diagnosed with Vitamin B12 deficiency

Banci L, Cantini F, Kozyreva T, Rubino JT

these strategies are all still in their infancy As 50% of patients with PD have comorbid Alzheimer disease (AD) pathology, targeting of tau and amyloid- could open novel avenues to alleviate or halt cognitive dysfunction Disease-modifying therapies under investigation in AD could also be of benefit in PD

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doi: 10.1016/j.it.2020.11.002 55 De FloraS.BalanskyR.La MaestraS

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