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This reaction can occur both non-enzymatically and through catalysis by glutathione peroxidase [14, 15]

Administration routes in these studies include intraperitoneal injection, intragastric (oral) gavage, and topical application as a thin cream layer, with the choice of route depending on the experimental model

NEJM 2011;365:15971604: 10.1056/NEJMoa1105816

[oai_citation:13PubMed]( Vasomotor tone: NO-mediated, largely endothelium-dependent vasorelaxation in aortic rings