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However, as research progressed, its therapeutic potential expanded beyond gastrointestinal applications

Neelakantan et al., Biochemical Pharmacology, 2018, gave diet-induced obese mice the compound and reported it significantly reduced body weight and white adipose mass, decreased adipocyte size, with food intake unchanged (PMID 29155147) [3]

Kidney and cardiovascular outcomes SURPASS-4 kidney composite HR 0.58, slower eGFR decline (-1.4 vs -3.6 mL/min/1.73m2/yr), UACR -6.8% vs +36.9%

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[DOI] [PMC free article] [PubMed] [Google Scholar] 113.Siler SQ, Neese RA, Hellerstein MK

NAD+ 1,000mg Summary Description: Nicotinamide adenine dinucleotide (NAD?) is a ubiquitous pyridine nucleotide coenzyme present in all living cells