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Flow cytometric analysis revealed that although intranasal IL-33 induced robust eosinophilia in both lung and BALF, melatonin significantly limited this increase ( Figures 2G, H ), even under melatonin receptor antagonism ( Figures 2G, H )

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In parallel, the kynurenine/tryptophan ratio was increased in symptomatic TTR-V30M carriers, supporting inflammatory activation in manifest disease

Mechanistic studies on three 2-oxoglutarate-dependent oxygenases of flavonoid biosynthesis

A reduction in cell death was also seen, but it did not reach statistical significance