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At present, regulatory agencies like the FDA and the European Commission evaluate CQDs on a case-by-case basis, irrespective of a specific regulatory procedure as these nanomaterials do not fit neatly within existing classifications for pharmaceuticals, biologics, or medical devices [172]

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Only data that had significance is reported in the results and discussion

ERK1/2 activation upregulates collagen gene expression and promotes cell proliferation critical for fibroblast proliferation, while p38 MAPK inhibition reduces inflammatory response

Proximal esophageal impedance baseline increases the yield of impedance-pH monitoring for GERD diagnosis and is associated with heartburn response to PPI

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